Grilled Chicken Spinach Panini

Featured in: Savory Bites

This Italian-American panini combines tender grilled chicken breast with fresh baby spinach, creamy mozzarella and Parmesan cheese, all bound together with fragrant garlic butter on rustic bread. The sandwich is pressed until golden and crispy on the outside while remaining warm and gooey inside.

Ready in just 30 minutes, it's an easy weeknight main dish that serves four. Customize with turkey, add roasted red peppers or tomatoes, and serve alongside a crisp salad or tomato soup for a complete meal.

Updated on Sun, 18 Jan 2026 09:35:00 GMT
Grilled Chicken Spinach Panini with golden, crusty bread and melted mozzarella, served warm with a side of tomato soup. Save
Grilled Chicken Spinach Panini with golden, crusty bread and melted mozzarella, served warm with a side of tomato soup. | cravebop.com

My husband brought home a panini press from a yard sale one Saturday morning, and I had no idea what to do with it. That evening, I grilled some leftover chicken breasts, pulled out whatever cheese was hiding in the drawer, and grabbed a handful of spinach before it wilted. The first press left golden grill marks across the bread, and the smell of garlic butter filling the kitchen made me realize this little appliance was about to earn its counter space. We ate standing up, cheese stretching between bites, and I knew I'd be making these paninis on repeat.

I started making these paninis on weeknights when my kids were too hungry to wait for anything complicated. One evening, my daughter watched me layer the chicken and cheese, then asked if she could press the sandwich herself. She stood on a step stool, carefully closing the lid, and her face lit up when she saw the grill marks appear. Now she insists on being the official panini presser, and I let her because it turns a regular dinner into something we do together.

Ingredients

  • Boneless, skinless chicken breasts: These grill up quickly and slice beautifully, but if they are thick, pound them out a bit so they cook evenly and do not dry out.
  • Olive oil: Brushing the chicken with oil before grilling keeps it juicy and helps the seasonings stick without sliding off.
  • Salt, black pepper, and dried Italian herbs: This simple trio gives the chicken just enough flavor to stand up to the garlic butter and cheese without overpowering anything.
  • Unsalted butter: Softened butter spreads easily and lets you control the salt level, especially since the cheeses add plenty of their own.
  • Garlic, minced: Fresh garlic mixed into the butter transforms ordinary bread into something you will want to eat on its own.
  • Fresh parsley: A little greenery in the garlic butter brightens everything and makes the kitchen smell like an Italian bistro.
  • Rustic Italian or sourdough bread: Sturdy bread holds up to the press and soaks in the garlic butter without falling apart or getting soggy.
  • Fresh baby spinach: It wilts just enough under the heat and adds a pop of color and a hint of earthiness that balances the richness.
  • Shredded mozzarella cheese: Melts into creamy, stretchy perfection and binds everything together in every bite.
  • Grated Parmesan cheese: Adds a sharp, nutty depth that keeps the panini from tasting one note and gives the crust a little extra crispness.

Instructions

Preheat the grill:
Get your grill pan or outdoor grill going over medium high heat so it is ready to sear the chicken as soon as you season it. A hot grill gives you those beautiful char marks and locks in the juices.
Season and grill the chicken:
Brush the chicken breasts with olive oil, sprinkle on the salt, pepper, and Italian herbs, then grill them for 5 to 6 minutes per side until they are cooked through and no longer pink in the center. Let them rest for 5 minutes before slicing so the juices redistribute and every slice stays moist.
Make the garlic butter:
In a small bowl, mix the softened butter with minced garlic and chopped parsley until everything is evenly combined. This spread is the secret to turning plain bread into something you will crave.
Assemble the sandwiches:
Lay out your bread slices and spread garlic butter on one side of each piece, then flip four slices over and layer on the sliced chicken, spinach, mozzarella, and Parmesan before topping with the remaining bread slices, buttered side facing out. The buttered outside is what gets golden and crispy in the press.
Press and cook:
Heat your panini press or a large skillet over medium heat, then place the sandwiches in the press or skillet, using a heavy pan to weigh them down if you do not have a press. Cook for 3 to 5 minutes per side until the bread is golden brown and the cheese is fully melted and gooey.
Slice and serve:
Cut each panini in half while it is still hot so the cheese stretches and the steam escapes. Serve immediately and watch them disappear.
Sliced grilled chicken and fresh spinach tucked inside a warm Grilled Chicken Spinach Panini, pressed until the cheese is perfectly gooey. Save
Sliced grilled chicken and fresh spinach tucked inside a warm Grilled Chicken Spinach Panini, pressed until the cheese is perfectly gooey. | cravebop.com

One afternoon, I made a batch of these paninis for a casual lunch with friends, and everyone kept asking for the recipe. I realized it was not just the food but the way we all stood around the counter, watching the press do its magic, laughing about whose sandwich would come out the prettiest. These paninis turn a simple meal into an excuse to gather, and that is when food matters most.

Choosing Your Bread

The bread you pick makes or breaks a panini because it has to hold up under pressure without turning into a crumbly mess. I have tried soft sandwich bread and it just smooshed flat and got soggy, so now I stick with rustic Italian loaves or sourdough that have a chewy crust and enough structure to crisp up beautifully. Ciabatta works too, but slice it horizontally so you get a good surface area for layering. Day old bread actually works better than fresh because it has less moisture and crisps up faster without steaming inside the press.

Making It Without a Panini Press

You do not need a panini press to make a great panini, and I have been using a cast iron skillet and a smaller heavy pan for years. Just heat your skillet over medium heat, place the sandwich in, then press down with another pan weighted with a few cans of beans or tomatoes. Flip it after a few minutes and press again until both sides are golden and the cheese is melted. The key is steady, even pressure and not rushing the heat, or the bread will burn before the cheese gets gooey.

Storing and Reheating Leftovers

Paninis are best eaten right away, but if you have leftovers, wrap them tightly in foil and store them in the fridge for up to two days. To reheat, skip the microwave because it will make the bread rubbery and sad. Instead, heat a skillet over medium low, place the panini in, and press it gently with a spatula until the bread crisps back up and the cheese softens again.

  • You can also reheat them in a 350 degree oven for about 10 minutes, wrapped loosely in foil to keep the bread from drying out.
  • If you want to prep ahead, assemble the sandwiches without buttering the outside, wrap them in plastic wrap, and store them in the fridge for up to a day before pressing.
  • Leftover grilled chicken keeps for three days in the fridge, so you can grill extra and have panini ready to assemble in minutes.
A close-up of a Grilled Chicken Spinach Panini, revealing layers of juicy chicken, vibrant spinach, and melty Parmesan on buttery bread. Save
A close-up of a Grilled Chicken Spinach Panini, revealing layers of juicy chicken, vibrant spinach, and melty Parmesan on buttery bread. | cravebop.com

Every time I make these paninis, I am reminded that the best meals do not have to be complicated or take hours. They just need good ingredients, a little bit of care, and the willingness to stand at the counter and enjoy the process.

Recipe Guide

Can I prepare the panini ahead of time?

You can assemble the panini up to 2 hours ahead and refrigerate it wrapped in foil. Press it directly from the fridge, adding 1-2 extra minutes to the cooking time.

What cheese works best for this panini?

Mozzarella melts beautifully and stays creamy, but provolone adds a slightly smoky flavor. You can also use fontina or a blend of both for richer taste.

How do I prevent the bread from drying out?

The garlic butter coating seals the bread and keeps it moist. Don't skip this step, and avoid over-pressing the panini, which can squeeze out the filling.

Can I use a regular skillet instead of a panini press?

Yes, place the sandwich in a heated skillet and weight it down with a heavy cast-iron pan or foil-wrapped bricks. Cook 3-5 minutes per side until golden.

What's the best way to slice the chicken for even cooking?

Pound the chicken breasts to uniform thickness before grilling, about 3/4 inch thick. This ensures even cooking and prevents dry edges.

Can I make this without dairy?

Substitute dairy-free cheese and vegan butter for the garlic butter spread. The flavor will be lighter, but the panini remains delicious and satisfying.

Grilled Chicken Spinach Panini

Juicy grilled chicken paired with fresh spinach, melted mozzarella, and garlic butter on toasted crusty bread.

Prep duration
15 min
Cook duration
15 min
Complete duration
30 min
Created by Lindsey Carter

Style Savory Bites

Skill level Easy

Heritage Italian-American

Output 4 Portions

Nutrition labels None specified

What you'll need

Chicken

01 2 boneless, skinless chicken breasts
02 1 tablespoon olive oil
03 1/2 teaspoon salt
04 1/2 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Garlic Butter

01 3 tablespoons unsalted butter, softened
02 2 cloves garlic, minced
03 1 tablespoon fresh parsley, finely chopped

Panini Assembly

01 8 slices rustic Italian or sourdough bread
02 2 cups fresh baby spinach, washed and dried
03 1 1/2 cups shredded mozzarella cheese
04 1/2 cup grated Parmesan cheese
05 Olive oil for brushing

Method

Phase 01

Prepare Grill Station: Preheat a grill pan or outdoor grill to medium-high heat.

Phase 02

Grill Chicken: Brush chicken breasts with olive oil and season with salt, pepper, and dried Italian herbs. Grill for 5-6 minutes per side until cooked through. Rest for 5 minutes, then slice thinly.

Phase 03

Make Garlic Butter: In a small bowl, combine softened butter, minced garlic, and chopped parsley until well mixed.

Phase 04

Prepare Bread: Lay out bread slices on a work surface. Spread garlic butter mixture on one side of each slice.

Phase 05

Layer Panini: On the unbuttered side of 4 bread slices, layer sliced grilled chicken, spinach, mozzarella cheese, and Parmesan cheese. Top with remaining bread slices, buttered side facing outward.

Phase 06

Press and Cook: Heat a panini press or large skillet over medium heat. Place assembled sandwiches in the press or skillet, using a heavy pan to weigh down if needed. Cook 3-5 minutes per side until bread is golden brown and cheese is melted.

Phase 07

Serve: Remove panini from heat, slice in half diagonally, and serve immediately while hot.

Tools needed

  • Grill pan or outdoor grill
  • Panini press or large skillet
  • Mixing bowl
  • Knife and cutting board

Allergy alerts

Always review ingredients for potential allergens and seek professional medical advice if uncertain.
  • Contains wheat from bread
  • Contains milk from cheese and butter
  • May contain gluten traces depending on bread source
  • May contain dairy traces depending on cheese source

Nutrition breakdown (per portion)

Values shown are estimates only - consult healthcare providers for specific advice.
  • Energy: 450
  • Fats: 20 g
  • Carbohydrates: 35 g
  • Proteins: 32 g